Computational Chemist

Cambridge, Cambridgeshire
CK Group- Science, Clinical and Technical
CK Group are recruiting for a highly motivated Computational Chemist to join a leading biopharmaceutical company focused on therapeutic areas in inflammation diseases, neurology and immunology. The successful candidate will be part of the Computational Chemistry team. This role will be based at their site in Cambridge on a permanent basis with flexibility of hybrid working.

The Role:
Fantastic opportunity to join an expanding team that are actively involved in multiple drug discovery projects, AI and structure-based drug discovery (SBDD) collaborations. Using the state-of-the-art CADD techniques, you will support and drive discovery projects from early stage to clinical candidate stage working closely with cross-functional teams (chemistry, pharmacology and structural biology).

Responsibilities:

• Contribute to multidisciplinary GPCR SBDD projects by applying a broad set of computational chemistry and cheminformatics approaches
• Develop customised computational chemistry and cheminformatics tools and workflows to extract, integrate and analyse complex chemical, structural, pharmacological and ADMET data within the context of SBDD.
• Play an active role in new initiatives, such as: Development of new computational chemistry CADD software via external collaborations; Structural bioinformatics and StaR data driven GPCR protein engineering and GPCR structure-based design of Targeted Protein Degraders

Your Background:

• PhD. or equivalent experience in computational chemistry, cheminformatics, or a related discipline
• Strong background in molecular recognition and the structural and physicochemical property determinants of small molecule binding to proteins
• Computational chemistry experience within a collaborative multi-disciplinary medicinal chemistry research environment
• Experience with molecular modelling, computer-aided drug design and cheminformatics software packages
• Experience in structure-based GPCR ligand design is considered beneficial
• Experience in computational structural biology, including the systematic analysis and use of X-ray crystallographic or cryo-EM data of protein-ligand complexes

Benefits:

• Competitive salary
• Discretionary bonuses.
• 25 days annual leave in addition to public holidays.
• Health and wellbeing benefits including a subsidised individual gym membership.

Apply:
It is essential that applicants hold entitlement to work in the UK. Please quote job reference 55652 in all correspondence.